SMART: Pfam domain RPEL

RPEL

PFAM accession number:	PF02755
Interpro abstract (IPR004018):	RPEL repeat (RPxxxEL) containing proteins are found in a wide range of metazoan organisms. RPEL repeats have been shown to be required for unpolymerised actin binding and proteins containing RPEL repeats are able to modify cell shape and/or are important in the regulation of gene expression by the actin cytoskeleton. RPEL repeats can be found in association with the SAP motif, which could be involved in DNA binding [ (PUBMED:12732141) (PUBMED:15620697) ]. Some proteins known to contain RPEL repeats are listed below: Mammalian myocardin, heart-specific serum response factor (SRF) co- activator. Vertebrate myocardin-related transcription factor A (MRTF-A or MAL), a signal-regulated SRF co-activator. Vertebrate myocardin-related transcription factor B (MRTF-B). Mammalian phosphatase and actin regulator 1 to 3.

PFAM accession number:

PF02755

Interpro abstract (IPR004018):

RPEL repeat (RPxxxEL) containing proteins are found in a wide range of metazoan organisms. RPEL repeats have been shown to be required for unpolymerised actin binding and proteins containing RPEL repeats are able to modify cell shape and/or are important in the regulation of gene expression by the actin cytoskeleton. RPEL repeats can be found in association with the SAP motif, which could be involved in DNA binding [ (PUBMED:12732141) (PUBMED:15620697) ].

Some proteins known to contain RPEL repeats are listed below:

Mammalian myocardin, heart-specific serum response factor (SRF) co- activator.
Vertebrate myocardin-related transcription factor A (MRTF-A or MAL), a signal-regulated SRF co-activator.
Vertebrate myocardin-related transcription factor B (MRTF-B).
Mammalian phosphatase and actin regulator 1 to 3.

This is a PFAM domain. For full annotation and more information, please see the PFAM entry RPEL