The domain within your query sequence starts at position 626 and ends at position 818; the E-value for the RecQ5 domain shown below is 3.1e-97.



PFAM accession number:PF06959
Interpro abstract (IPR010716): This entry represents a domain found in RECQ5. RecQ helicases is a group of highly conserved 3'-5' DNA helicases involved in maintaining genomic stability. RECQ5 plays an important role in DNA replication, transcription and repair [(PUBMED:20643585), (PUBMED:20348101)]. It interacts with RNA polymerase II to reduce transcription-associated replication impairment and recombination [(PUBMED:20231364)]. As a helicase, it can disrupt RAD51 filaments assembled on ssDNA, thereby inhibiting homologous recombination [(PUBMED:23748380)]. It also participates in psoralen-induced interstrand cross-link repair [(PUBMED:23715498)]. It stimulates DNA decatenation mediated by TOP2A [(PUBMED:22013166)].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry RecQ5