RsgA_GTPase

• PFAM accession number: PF03193
• Interpro abstract (IPR010914):

  GTPases function as crucial molecular switches in a broad variety of biochemical processes. The majority of GTPases form a vast class of evolutionarily related proteins within the broader class of P-loop-containing ATPases. The P-loop GTPases share a conserved amino acid sequence G1-G3-G4 motif pattern (G2 is less well conserved) present in the GTPase domain. The Escherichia coli protein EngC (also known as RsgA) represents a protein family whose members are broadly conserved in bacteria and are indispensable for growth. The GTPase domain of RsgA is very similar to several P-loop GTPases, but differs in having a circular permutation of the GTPase structure described by a G4-G1-G3 pattern [ (PUBMED:12220175) ]. The RsgA-type GTPase domain is predominantly bacterial, with a probable acquisition by plants from chloroplasts [ (PUBMED:11916378) ].

• GO function: GTP binding (GO:0005525), GTPase activity (GO:0003924)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry RsgA_GTPase