The domain within your query sequence starts at position 48 and ends at position 363; the E-value for the SARAF domain shown below is 4.8e-98.
LLSLLLVAGPALGWNDPDRILLRDVKALTLYSDRYTTSRRLDPIPQLKCVGGTAGCEAYT PRVIQCQNKGWDGYDVQWECKTDLDIAYKFGKTVVSCEGYESSEDQYVLRGSCGLEYNLD YTELGLKKLKESGKHQGFSDYYHKLYSSDSCGFITIAVLFVLAFAVYKLFLSDGQGSPPP YSEHPPYSEHSQRFASAAGAPPPGFKSEFTGPQNTGYGASSGFGSAFGGQGYGSSGPGFW SGLGAGGLLGYLFGSNRAATPFSDSWYHPAYPPSHSGAWNSRAYSPLGGGAGSYCASSNA DSRTRTASGYGGTRRR
SARAF |
---|
PFAM accession number: | PF06682 |
---|---|
Interpro abstract (IPR009567): | SARAF is an endoplasmic reticulum membrane resident protein that serves as a negative regulator of store-operated Ca2+ entry (SOCE) involved in protecting cells from Ca2+ overfilling. It is a single pass ER membrane protein whose systolic-facing domain is responsible for activity and whose luminary-facing domain carries out a regulatory function in conjunction with another membrane protein STIM, an ER single pass membrane protein that detects changes in ER Ca2+ levels through its EF-hand, conserved Ca2+ binding domain. STIM is the major target for SARAF regulation, and thus SARAF negatively regulates the SOCE entry of calcium into cells protecting them from overfilling [ (PUBMED:22464749) ]. |
GO process: | regulation of store-operated calcium entry (GO:2001256) |
GO component: | integral component of endoplasmic reticulum membrane (GO:0030176) |
This is a PFAM domain. For full annotation and more information, please see the PFAM entry SARAF