The domain within your query sequence starts at position 2601 and ends at position 2700; the E-value for the SHR-BD domain shown below is 8.4e-10.



PFAM accession number:PF06650
Interpro abstract (IPR009543):

This entry represents a domain, known as SHR-BD, found in vacuolar protein sorting-associated protein 13 (VPS13). In plants, this domain is found to be the region which interacts with SHR or the SHORT-ROOT transcription factor, a regulator of root-growth and asymmetric cell division that separates ground tissue into endodermis and cortex. The plant protein containing the SHR-BD is named SHRUBBY or SHBY (Q9FT44) [(PUBMED:2344435)].

Proteins containing this domain may play a role in the control of protein cycling through the trans-Golgi network. Vacuolar sorting protein is an ATPase required for endosomal trafficking [(PUBMED:10637304)]. Defects in the human protein VPS13A cause chorea-acanthocytosis, an autosomal recessive neurodegenerative disorder characterised by the gradual onset of hyperkinetic movements and abnormal erythrocyte morphology [(PUBMED:11381253)].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry SHR-BD