The domain within your query sequence starts at position 2 and ends at position 115; the E-value for the SKA2 domain shown below is 3.4e-39.



PFAM accession number:PF16740
Interpro abstract (IPR042091):

This entry represents the N-terminal domain of Ska2.

Spindle and kinetochore-associated protein 2 (Ska2) is a component of the SKA1 complex (consists of Ska1, Ska2, and Ska3/Rama1), a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation [ (PUBMED:17093495) ]. It is required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint [ (PUBMED:22483620) ]. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerisation-coupled manner. In the complex, it is required for SKA1 localisation [ (PUBMED:19289083) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry SKA2