The domain within your query sequence starts at position 71 and ends at position 149; the E-value for the SPC12 domain shown below is 2.1e-35.



PFAM accession number:PF06645
Interpro abstract (IPR009542):

This family consists of several microsomal signal peptidase 12 kDa subunit proteins. Translocation of polypeptide chains across the endoplasmic reticulum (ER) membrane is triggered by signal sequences. Subsequently, signal recognition particle interacts with its membrane receptor and the ribosome-bound nascent chain is targeted to the ER where it is transferred into a protein-conducting channel. At some point, a second signal sequence recognition event takes place in the membrane and translocation of the nascent chain through the membrane occurs. The signal sequence of most secretory and membrane proteins is cleaved off at this stage. Cleavage occurs by the signal peptidase complex (SPC) as soon as the lumenal domain of the translocating polypeptide is large enough to expose its cleavage site to the enzyme. The signal peptidase complex is possibly also involved in proteolytic events in the ER membrane other than the processing of the signal sequence, for example the further digestion of the cleaved signal peptide or the degradation of membrane proteins. Mammalian signal peptidase is as a complex of five different polypeptide chains. This family represents the 12 kDa subunit (SPC12) [(PUBMED:8632014)].

GO process:signal peptide processing (GO:0006465)
GO component:integral component of membrane (GO:0016021), signal peptidase complex (GO:0005787)
GO function:peptidase activity (GO:0008233)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry SPC12