The domain within your query sequence starts at position 2 and ends at position 44; the E-value for the SPO11_like domain shown below is 6.3e-28.



PFAM accession number:PF03533
Interpro abstract (IPR004084):

Spo11 is a meiosis-specific protein in yeast that covalently binds to DNA double-strand breaks (DSBs) during the early stages of meiosis [ (PUBMED:10534401) ]. These DSBs initiate homologous recombination, which is required for chromosomal segregation and generation of genetic diversity during meiosis. Mouse and human homologues of Spo11 have been cloned and characterised. The proteins are 82% identical and share ~25% identity with other family members. Mouse Spo11 has been localised to chromosome 2H4, and human SPO11 to chromosome 20q13.2-q13.3, a region amplified in some breast and ovarian tumours [ (PUBMED:10534401) ].

Similarity between SPO11 and archaebacterial TOP6A proteins points to evolutionary specialisation of a DNA-cleavage function for meiotic recombination [ (PUBMED:10622720) ]. Note that the yeast SPO11 protein shares far less similarity to other SPO11 proteins than the human and mouse homologues do to each other.

GO process:reciprocal meiotic recombination (GO:0007131)
GO function:DNA binding (GO:0003677)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry SPO11_like