SMART: Pfam domain SeqA

SeqA

PFAM accession number:	PF03925
Interpro abstract (IPR026577):	The C-terminal domain binds DNA, binding to hemimethylated GATC sequences at oriC [ (PUBMED:12379844) (PUBMED:14704346) ]. The structure of the C-terminal domain consists of seven alpha-helices and three-stranded beta-sheet. The binding of the negative modulator of initiation of replication (SeqA) protein to hemimethylated GATC sequences is important in the negative modulation of chromosomal initiation at oriC, and in the formation of SeqA foci necessary for Escherichia coli chromosome segregation [ (PUBMED:11457824) ]. SeqA tetramers are able to aggregate or multimerize in a reversible, concentration-dependent manner [ (PUBMED:11457824) ]. Apart from its function in the control of DNA replication, SeqA may also be a specific transcription factor [ (PUBMED:11442835) ].
GO function:	DNA binding (GO:0003677)

PFAM accession number:

PF03925

Interpro abstract (IPR026577):

The C-terminal domain binds DNA, binding to hemimethylated GATC sequences at oriC [ (PUBMED:12379844) (PUBMED:14704346) ]. The structure of the C-terminal domain consists of seven alpha-helices and three-stranded beta-sheet.

The binding of the negative modulator of initiation of replication (SeqA) protein to hemimethylated GATC sequences is important in the negative modulation of chromosomal initiation at oriC, and in the formation of SeqA foci necessary for Escherichia coli chromosome segregation [ (PUBMED:11457824) ]. SeqA tetramers are able to aggregate or multimerize in a reversible, concentration-dependent manner [ (PUBMED:11457824) ]. Apart from its function in the control of DNA replication, SeqA may also be a specific transcription factor [ (PUBMED:11442835) ].

GO function:

DNA binding (GO:0003677)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry SeqA