SMART: Pfam domain Skp1

The domain within your query sequence starts at position 1 and ends at position 28; the E-value for the Skp1_POZ domain shown below is 6.8e-11.

DGEIFEVDVEIAKQSVTIKTMLEEKKLY

Skp1_POZ

PFAM accession number:	PF03931
Interpro abstract (IPR016073):	SKP1 (together with SKP2) was identified as an essential component of the cyclin A-CDK2 S phase kinase complex [ (PUBMED:10205047) ]. It was found to bind several F-box containing proteins (e.g., Cdc4, Skp2, cyclin F) and to be involved in the ubiquitin protein degradation pathway. A yeast homologue of SKP1 (P52286) was identified in the centromere bound kinetochore complex [ (PUBMED:8670864) ] and is also involved in the ubiquitin pathway [ (PUBMED:9390558) ]. In Dictyostelium discoideum (Slime mold) FP21 was shown to be glycosylated in the cytosol and has homology to SKP1 [ (PUBMED:7852383) ]. This entry represents a POZ domain with a core structure consisting of beta(2)/alpha(2)/beta(2)/alpha(2) in two layers, alpha/beta. This domain is found at the N-terminal of SKP1 proteins [ (PUBMED:11099048) ] as well as in subunit D of the centromere DNA-binding protein complex Cbf3 [ (PUBMED:12553912) ].
GO process:	ubiquitin-dependent protein catabolic process (GO:0006511)

PFAM accession number:

PF03931

Interpro abstract (IPR016073):

SKP1 (together with SKP2) was identified as an essential component of the cyclin A-CDK2 S phase kinase complex [ (PUBMED:10205047) ]. It was found to bind several F-box containing proteins (e.g., Cdc4, Skp2, cyclin F) and to be involved in the ubiquitin protein degradation pathway. A yeast homologue of SKP1 (P52286) was identified in the centromere bound kinetochore complex [ (PUBMED:8670864) ] and is also involved in the ubiquitin pathway [ (PUBMED:9390558) ]. In Dictyostelium discoideum (Slime mold) FP21 was shown to be glycosylated in the cytosol and has homology to SKP1 [ (PUBMED:7852383) ].

This entry represents a POZ domain with a core structure consisting of beta(2)/alpha(2)/beta(2)/alpha(2) in two layers, alpha/beta. This domain is found at the N-terminal of SKP1 proteins [ (PUBMED:11099048) ] as well as in subunit D of the centromere DNA-binding protein complex Cbf3 [ (PUBMED:12553912) ].

GO process:

ubiquitin-dependent protein catabolic process (GO:0006511)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Skp1_POZ