The domain within your query sequence starts at position 143 and ends at position 299; the E-value for the SpoU_methylase domain shown below is 3.2e-31.

QLWLVLEGLQDPRNLGAVMRSAHFLGVDRVITSQRNSCPLTPVVSKASAGAMEVMDVFAT
PDLPGFLQAKAQQGWLVVGTVGCPGPEISQSSKVPITSCLEFVWDRPTLLVLGSEGSGLS
QEVFASCQLLLTILPRRHLPPGLESLNVSVATGILLH

SpoU_methylase

SpoU_methylase
PFAM accession number:PF00588
Interpro abstract (IPR001537): This entry represents a domain found in the spoU protein from E. coli that shows strong similarities to previously characterised 2'-O-methyltransferases [(PUBMED:9321663), (PUBMED:8265370)]. The Mrm1 protein of Saccharomyces cerevisiae has been shown to be required for ribose methylation at a universally conserved nucleotide in the peptidyl transferase centre of the mitochondrial large ribosomal RNA (21S rRNA). Cells reduced in this activity were deficient in formation of functional large subunits of the mitochondrial ribosome. The Mrm1 protein catalyzes the site-specific formation of 2'-O-methylguanosine on in vitro transcripts of both mitochondrial 21S rRNA and E. coli 23S rRNA providing evidence for an essential modified nucleotide in rRNA [(PUBMED:8266080)].
GO process:RNA processing (GO:0006396)
GO function:RNA methyltransferase activity (GO:0008173), RNA binding (GO:0003723)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry SpoU_methylase