SMART: Pfam domain Stealth

The domain within your query sequence starts at position 73 and ends at position 101; the E-value for the Stealth_CR1 domain shown below is 6.6e-14.

MPIDVVYTWVNGTDLELLKELQQVREHME

Stealth_CR1

PFAM accession number:	PF17101
Interpro abstract (IPR031358):	This entry represents the first of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. CR1 carries a well-conserved IDVVYT sequence-motif. The domain is found in tandem with CR2, CR3 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system [ (PUBMED:16299590) ].

PFAM accession number:

PF17101

Interpro abstract (IPR031358):

This entry represents the first of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. CR1 carries a well-conserved IDVVYT sequence-motif. The domain is found in tandem with CR2, CR3 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system [ (PUBMED:16299590) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Stealth_CR1