Suf

• PFAM accession number: PF05843
• Interpro abstract (IPR008847):

  This domain consists of several eukaryotic suppressor of forked (Suf) like proteins. The Drosophila melanogaster suppressor of forked [Su(f)] protein shares homology with the Saccharomyces cerevisiae RNA14 protein and the 77kDa subunit of Homo sapiens cleavage stimulation factor, which are proteins involved in mRNA 3' end formation. This suggests a role for Su(f) in mRNA 3' end formation in Drosophila. The su(f) gene produces three transcripts; two of them are polyadenylated at the end of the transcription unit, and one is a truncated transcript, polyadenylated in intron 4. It is thought that su(f) plays a role in the regulation of poly(A) site utilisation and the GU-rich sequence is important for this regulation to occur [ (PUBMED:9826695) ].

• GO process: mRNA processing (GO:0006397)
• GO component: nucleus (GO:0005634)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Suf