Syd

• PFAM accession number: PF07348
• Interpro abstract (IPR009948):

  This family contains the Syd protein that has been implicated in the Sec-dependent transport of polypeptides across the inner membrane in bacteria. Syd has been shown to bind the SecY subunit of membrane-embedded SecYEG heterotrimer (also known as core translocon or SecY complex) which is a conserved protein-conducting channel essential for the biogenesis of most of the secretory and integral membrane proteins [ (PUBMED:19139097) ]. The SecY-binding site of Syd is a conserved concave and electronegative groove that forms interactions with the electropositive loops of the SecY subunit [ (PUBMED:9645430) ]. Syd is also known to verify the proper assembly of the SecY complex in the membrane by interfering with protein translocation only when the channel displays abnormal SecY-SecE associations [ (PUBMED:21632250) ].

• GO component: cytoplasmic side of plasma membrane (GO:0009898)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Syd