The domain within your query sequence starts at position 209 and ends at position 409; the E-value for the TF_AP-2 domain shown below is 7.8e-94.



PFAM accession number:PF03299
Interpro abstract (IPR013854):

Activator protein-2 (AP-2) transcription factors constitute a family of closely related and evolutionarily conserved proteins that bind to the DNA consensus sequence GCCNNNGGC and stimulate target gene transcription [ (PUBMED:2010091) (PUBMED:1998122) ]. Four different isoforms of AP-2 have been identified in mammals, termed AP-2 alpha, beta, gamma and delta. Each family member shares a common structure, possessing a proline/glutamine-rich domain in the N-terminal region, which is responsible for transcriptional activation [ (PUBMED:2010091) ], and a helix-span-helix domain in the C-terminal region, which mediates dimerisation and site-specific DNA binding [ (PUBMED:1998122) ].

The AP-2 family have been shown to be critical regulators of gene expression during embryogenesis. They regulate the development of facial prominence and limb buds, and are essential for cranial closure and development of the lens [ (PUBMED:11137286) ]; they have also been implicated in tumourigenesis. AP-2 protein expression levels have been found to affect cell transformation, tumour growth and metastasis, and may predict survival in some types of cancer [ (PUBMED:9632718) (PUBMED:10864206) ]

This entry represents the C-terminal region of these proteins, including the helix-span-helix domain.

This is a PFAM domain. For full annotation and more information, please see the PFAM entry TF_AP-2