The domain within your query sequence starts at position 128 and ends at position 295; the E-value for the THF_DHG_CYH_C domain shown below is 1.1e-67.

TSVSAGKLARGDLNDCFIPCTPKGCLELIKEAGVQIAGRHAVVVGRSKIVGAPMHDLLLW
NNATVTTCHSKTANLDKEVNKGDILVVATGQPEMVKGEWIKPGAVVIDCGINYVPDDTKP
NGRKVVGDVAYDEAKERASFITPVPGGVGPMTVAMLMQSTVESAQRFL

THF_DHG_CYH_C

THF_DHG_CYH_C
PFAM accession number:PF02882
Interpro abstract (IPR020631):

Enzymes that participate in the transfer of one-carbon units require the coenzyme tetrahydrofolate (THF). Various reactions generate one-carbon derivatives of THF, which can be interconverted between different oxidation states by methylene-THF dehydrogenase ( EC 1.5.1.5 ), methenyl-THF cyclohydrolase ( EC 3.5.4.9 ) and formyl-THF synthetase ( EC 6.3.4.3 ) [ (PUBMED:2541774) (PUBMED:8485162) ]. The dehydrogenase and cyclohydrolase activities are expressed by a variety of multifunctional enzymes, including the tri-functional eukaryotic C1-tetrahydrofolate synthase [ (PUBMED:2541774) ]; a bifunctional eukaryotic mitochondrial protein; and the bifunctional Escherichia coli folD protein [ (PUBMED:2541774) (PUBMED:8485162) ]. Methylene-tetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclo-hydrolase share an overlapping active site [ (PUBMED:2541774) ], and as such are usually located together in proteins, acting in tandem on the carbon-nitrogen bonds of substrates other than peptide bonds.

This entry represents the NAD(P)-binding domain found in these enzymes.

GO function:methylenetetrahydrofolate dehydrogenase (NADP+) activity (GO:0004488)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry THF_DHG_CYH_C