The domain within your query sequence starts at position 1 and ends at position 138; the E-value for the TP_methylase domain shown below is 3.7e-22.
MLYLIGLGLGDAKDITVKGLEVVRRCSRVYLEAYTSVLTVGKEALEEFYGRKLILADREE
VEQEADNIFKDADVSDVAFLVVGDPFGATTHSDLILRATKLGIPYQVIHNASIMNAVGCC
GLQVMPQRKCVLFPGSYK
TP_methylase |
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PFAM accession number: | PF00590 |
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Interpro abstract (IPR000878): |
Tetrapyrroles are large macrocyclic compounds derived from a common biosynthetic pathway [ (PUBMED:11215515) ]. The end-product, uroporphyrinogen III, is used to synthesise a number of important molecules, including cobalamin (vitamin B12), haem, sirohaem, chlorophyll, coenzyme F430 and phytochromobilin [ (PUBMED:17227226) ]. These enzymes catalyse the methylation of their substrates using S-adenosyl-L-methionine as a methyl source. Enzymes in this family include: - Uroporphyrinogen III methyltransferase ( EC 2.1.1.107 ) (SUMT), which catalyses the conversion of uroporphyrinogen III to precorrin-2 at the first branch-point of the tetrapyrrole synthesis pathway, directing the pathway towards cobalamin or sirohaem synthesis [ (PUBMED:15522295) ].
- Precorrin-2 C20-methyltransferase CobI/CbiL ( EC 2.1.1.130 ), which introduces a methyl group at C-20 on precorrin-2 to produce precorrin-3A during cobalamin biosynthesis. This reaction is key to the conversion of a porphyrin-type tetrapyrrole ring to a corrin ring [ (PUBMED:17229157) ]. In some species, this enzyme is part of a bifunctional protein.
- Precorrin-4 C11-methyltransferase CobM/CbiF ( EC 2.1.1.133 ), which introduces a methyl group at C-11 on precorrin-4 to produce precorrin-5 during cobalamin biosynthesis [ (PUBMED:16866557) ].
- Sirohaem synthase CysG ( EC 2.1.1.107 ), domains 4 and 5, which synthesizes sirohaem from uroporphyrinogen III, at the first branch-point in the tetrapyrrole biosynthetic pathway, directing the pathway towards sirohaem synthesis [ (PUBMED:14595395) ].
- Diphthine synthase ( EC 2.1.1.98 ), which carries out the methylation step during the modification of a specific histidine residue of elongation factor 2 (EF-2) during diphthine synthesis.
This entry represents a tetrapyrrole methylase domain, which consist of two non-similar subdomains [ (PUBMED:15522295) ].
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GO function: | methyltransferase activity (GO:0008168) |
This is a PFAM domain. For full annotation and more information, please see the PFAM entry TP_methylase