The domain within your query sequence starts at position 8 and ends at position 144; the E-value for the TYW3 domain shown below is 8.1e-45.

GRWKAQSLSKADLSRKGSVDEDAVEVVELLNSREEFFTTSSCAGRILLLDGSTEGSGVQK
QHCCWLLVTHKPCARDDVMAALKGATSEAVLKFEPFILHVQCRTLQDAQTLHSVAIDSGF
RNSGITVGKRGKTMLVL

TYW3

TYW3
PFAM accession number:PF02676
Interpro abstract (IPR003827):

The methyltransferase TYW3 (tRNA-yW- synthesising protein 3) has been identified in yeast to be involved in wybutosine (yW) biosynthesis [ (PUBMED:16642040) ]. yW is a complexly modified guanosine residue that contains a tricyclic base and is found at the 3'-position adjacent the anticodon of phenylalanine tRNA. TYW3 is an N-4 methylase that methylates yW-86 to yield yW-72 in an Ado-Met-dependent manner [ (PUBMED:16642040) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry TYW3