The domain within your query sequence starts at position 11 and ends at position 191; the E-value for the Thymidylate_kin domain shown below is 6.7e-52.

LEGVDRAGKTTQGLKLVTALCASGHRAELLRFPERSTEIGKLLNSYLEKKTELEDHSVHL
LFSANRWEQVPLIKAKLNQGVTLVLDRYAFSGVAFTGAKENFSLDWCKQPDVGLPKPDLI
LFLQLQLLDAAARGEFGLERYETGTFQKQVLLCFQQLMEEKNLNWKVVDASKSIEEVHKE
I

Thymidylate_kin

Thymidylate_kin
PFAM accession number:PF02223
Interpro abstract (IPR039430):

Thymidylate kinase ( EC 2.7.4.9 ; dTMP kinase) catalyzes the phosphorylation of thymidine 5'-monophosphate (dTMP) to form thymidine 5'-diphosphate (dTDP) in the presence of ATP and magnesium:

ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate

Thymidylate kinase is an ubiquitous enzyme of about 25 Kd and is important in the dTTP synthesis pathway for DNA synthesis. The function of dTMP kinase in eukaryotes comes from the study of a cell cycle mutant, cdc8, in Saccharomyces cerevisiae. Structural and functional analyses suggest that the cDNA codes for authentic human dTMP kinase. The mRNA levels and enzyme activities corresponded to cell cycle progression and cell growth stages [ (PUBMED:8024690) ].

This entry represents a domain found in thymidylate kinase and mitochondrial UMP-CMP kinase.

From a phylogenetic analysis, human mitochondrial UMP-CMP kinase has been shown to be closer to thymidylate kinase than to cytosolic UMP-CMP kinase. It phosphorylates dUMP, dCMP, CMP, and UMP with ATP as phosphate donor [ (PUBMED:17999954) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Thymidylate_kin