TisB_toxin

• PFAM accession number: PF13939
• Interpro abstract (IPR025211):

  TisB (toxicity-induced by SOS B) is an SOS-induced toxic peptide and is part of the type I toxin-antitoxin system, in which the antitoxin is a non-coding RNA. It is a hydrophobic membrane-spanning protein that inhibits cell growth [ (PUBMED:18761622) ]. Its expression is inhibited by the antisense RNA IstR-1 [ (PUBMED:15620655) ]. TisB appears to induce a persister state by dissipating transmembrane potential, thus depleting ATP. Persister cells, unable to grow until the persister state changes, survive a number of challenges, including exposure to most antibiotics [ (PUBMED:18761622) (PUBMED:23062338) (PUBMED:22728134) ].

• GO process: SOS response (GO:0009432), dormancy process (GO:0022611)
• GO component: integral component of plasma membrane (GO:0005887)
• GO function: anion channel activity (GO:0005253)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry TisB_toxin