Tna_leader

• PFAM accession number: PF08053
• Interpro abstract (IPR012620):

  This entry defines the apparent leader peptides of tryptophanase operons in Escherichia coli, Vibrio cholerae, Photobacterium profundum, Haemophilus influenzae, and related species. It has been suggested that these peptides act in cis to alter the behaviour of the translating ribosome [ (PUBMED:9045840) ].

  The tryptophanese (tna) operon leader peptide catalyses the degradation of L-tryptophan to indole, pyruvate and ammonia, enabling the bacteria to utilise tryptophan as a source of carbon, nitrogen and energy. The tna operon of Escherichia coli contains two major structural genes, tnaA and tnaB. Preceding tnaA in the tna operon is a 319 -nucleotide transcribed regulatory region that contains the coding region for a 24-residue leader peptide, TnaC. The RNA sequence in the vicinity of the tnaC stop codon is rich in Cytidylate residues which is required for efficient Rho -dependent termination in the leader region of the tna operon [ (PUBMED:14563884) ].

• GO process: transcriptional attenuation by ribosome (GO:0031556), regulation of DNA-templated transcription, termination (GO:0031554)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Tna_leader