SMART: Pfam domain UPF0016

The domain within your query sequence starts at position 237 and ends at position 311; the E-value for the UPF0016 domain shown below is 4.6e-26.

VQALTLTFLAEWGDRSQLTTIVLAAREDPYGVAVGGTVGHCLCTGLAVIGGRMIAQKISV
RTVTIIGGIVFLAFA

UPF0016

PFAM accession number:	PF01169
Interpro abstract (IPR001727):	Budding yeast Gdt1 is a Golgi-localized calcium transporter required for stress-induced calcium signalling and protein glycosylation [ (PUBMED:27075443) ]. Its human homologue, TMEM165, may be a Golgi Ca2(+)/H(+) antiporter [ (PUBMED:24530912) ]. Defects in the human protein TMEM165 cause a subtype of Congenital Disorders of Glycosylation [ (PUBMED:23569283) ]. In Arabidopsis this protein is variously known as CCHA1 (a chloroplast-localized potential Ca(2+)/H(+) antiporter), chloroplastic PAM71 (photosynthesis affected mutant 71), and GDT1-like protein 1, chloroplastic. It has been reported to be a putative chloroplast-localized Ca(2+)/H(+) antiporter with critical functions in the regulation of PSII and in chloroplast Ca(2+) and pH homeostasis [ (PUBMED:27302341) ]. It has also been suggested that it may function in Mn(2+) uptake into thylakoids, ensuring optimal PSII performance [ (PUBMED:27020959) ].

PFAM accession number:

PF01169

Interpro abstract (IPR001727):

Budding yeast Gdt1 is a Golgi-localized calcium transporter required for stress-induced calcium signalling and protein glycosylation [ (PUBMED:27075443) ]. Its human homologue, TMEM165, may be a Golgi Ca2(+)/H(+) antiporter [ (PUBMED:24530912) ]. Defects in the human protein TMEM165 cause a subtype of Congenital Disorders of Glycosylation [ (PUBMED:23569283) ]. In Arabidopsis this protein is variously known as CCHA1 (a chloroplast-localized potential Ca(2+)/H(+) antiporter), chloroplastic PAM71 (photosynthesis affected mutant 71), and GDT1-like protein 1, chloroplastic. It has been reported to be a putative chloroplast-localized Ca(2+)/H(+) antiporter with critical functions in the regulation of PSII and in chloroplast Ca(2+) and pH homeostasis [ (PUBMED:27302341) ]. It has also been suggested that it may function in Mn(2+) uptake into thylakoids, ensuring optimal PSII performance [ (PUBMED:27020959) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry UPF0016