VanY

• PFAM accession number: PF02557
• Interpro abstract (IPR003709):

  These proteins are metallopeptidases belonging to MEROPS peptidase family M15 (clan MD), subfamily M15B (vanY D-Ala-D-Ala carboxypeptidase).

  Acquired VanA- and VanB-type glycopeptide resistance in enterococci is due to synthesis of modified peptidoglycan precursors terminating in D-lactate. As opposed to VanA-type strains which are resistant to both vancomycin and teicoplanin, VanB-type strains remain teicoplanin susceptible [ (PUBMED:8631706) ]. The vanY gene was necessary for synthesis of the vancomycin-inducible D,D-carboxypeptidase EC 3.4.16.4 activity previously proposed to be responsible for glycopeptide resistance. However, this activity was not required for peptidoglycan synthesis in the presence of glycopeptides [ (PUBMED:1398115) ].

• GO process: proteolysis (GO:0006508)
• GO function: peptidase activity (GO:0008233)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry VanY