SMART: Pfam domain VapB

VapB_antitoxin

PFAM accession number:	PF09957
Interpro abstract (IPR019239):	VapB is the antitoxin of a bacterial toxin-antitoxin gene pair. The cognate toxin is VapC ( IPR007712 ). The family contains several related antitoxins from Cyanobacteria and Actinobacterial families. Antitoxins of this class carry an N-terminal ribbon-helix-helix domain, RHH, that is highly conserved across all type II bacterial antitoxins, which dimerises with the RHH domain of a second VapB molecule. A hinge section follows the RHH, with an additional pair of flexible alpha helices at the C terminus. This C terminus is the Toxin-binding region of the dimer, and so is specific to the cognate toxin, whereas the RHH domain has the specific function of lying across the RNA-binding groove of the toxin dimer and inactivating the active-site - a more general function of all antitoxins [ (PUBMED:15718296) (PUBMED:20011113) ].

PFAM accession number:

PF09957

Interpro abstract (IPR019239):

VapB is the antitoxin of a bacterial toxin-antitoxin gene pair. The cognate toxin is VapC ( IPR007712 ). The family contains several related antitoxins from Cyanobacteria and Actinobacterial families. Antitoxins of this class carry an N-terminal ribbon-helix-helix domain, RHH, that is highly conserved across all type II bacterial antitoxins, which dimerises with the RHH domain of a second VapB molecule. A hinge section follows the RHH, with an additional pair of flexible alpha helices at the C terminus. This C terminus is the Toxin-binding region of the dimer, and so is specific to the cognate toxin, whereas the RHH domain has the specific function of lying across the RNA-binding groove of the toxin dimer and inactivating the active-site - a more general function of all antitoxins [ (PUBMED:15718296) (PUBMED:20011113) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry VapB_antitoxin