The domain within your query sequence starts at position 78 and ends at position 108; the E-value for the WSK domain shown below is 4.7e-13.



PFAM accession number:PF03832
Interpro abstract (IPR001573):

Cell signalling mediated via GPCRs (G-protein-coupled receptors) involves the assembly of receptors, G-proteins, effectors and downstream elements into complexes that approach in design 'solid-state' signalling devices. Scaffold molecules, such as the AKAPs (A-kinase anchoring proteins), were discovered more than a decade ago and represent dynamic platforms, enabling multivalent signalling [(PUBMED:12546660)]. This family of functionally related proteins is classified on the basis of their ability to associate with the PKA holoenzyme inside cells. A shared property of most, if not all, AKAPs is the ability to form multivalent signal transduction complexes.

Each anchoring protein contains at least two functional motifs [(PUBMED:8968497)]. The conserved PKA binding motif forms an amphipathic helix of 14-18 residues that interacts with hydrophobic determinants located in the extreme N terminus of the regulatory subunit dimmer. The subcellular address of each AKAP is encoded by a unique targeting motif. Gravin, an autoantigen recognised by serum from myasthenia gravis patients contains 3 repeats of this domain [(PUBMED:9000000)].

The WSK motif is short motif, named after three conserved residues found in the WXSXK motif, found in protein kinase A anchoring proteins.

GO process:signal transduction (GO:0007165), protein targeting (GO:0006605)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry WSK