SMART: Pfam domain WTX

The domain within your query sequence starts at position 89 and ends at position 556; the E-value for the WTX domain shown below is 3.5e-128.

SLNKSKTHDGLSEASQGPEDVVIEETDLSTPLSKSSAQFPSSQSANGALEIGSKHKTSGT
EAIEKAGVEKVPSVHKPKKSLKSFFSSIRRHRKGKTSGADQSVPGAKELEGARTRSHEHV
SSISLPSSEEIFRDTRKENAKPQDAPGPKMSPAQVHFSPTTEKAACKNPEKLTRTCASEF
MQPKPVLEGGSLEEPHTSETEGKVVAGEVNPPNGPVGDQLSLLFGDVTSLKSFDSLTGCG
DIIAEQDMDSMTDSMASGGQRANRDGTKRSSCLVTYQGGGEEMALPDDDDNDDEEEEEEE
EEEEEEEEEEEEEEEEEEEEELLEDEEEVKDGEENDDLEYLWASAQIYPRFNMNLGYHTA
ISPSHQGYMLLDPVQSYPNLGLGELLTPQSDQQESAPNSDEGYYDSTTPGFEDDSGEALG
LAHRDCLPRDSYSGDALYEFYEPDDSLEHSPPGDDCLYDLRGRNSEML

WTX

PFAM accession number:	PF09422
Interpro abstract (IPR019003):	This entry includes APC membrane recruitment protein 1/2/3 (Amer1/2/3). Amer1, also known as WTX, binds to the tumour suppressor adenomatous polyposis coli and acts as an inhibitor of Wnt signaling by inducing beta-catenin degradation [ (PUBMED:21498506) ]. Amer2 is a negative regulator of Wnt/beta-catenin signaling involved in neuroectodermal patterning [ (PUBMED:22128170) ]. WTX is a novel gene mutated in a proportion of Wilms' tumors and in patients suffering from sclerosing bone dysplasia [ (PUBMED:20843316) ].

PFAM accession number:

PF09422

Interpro abstract (IPR019003):

This entry includes APC membrane recruitment protein 1/2/3 (Amer1/2/3). Amer1, also known as WTX, binds to the tumour suppressor adenomatous polyposis coli and acts as an inhibitor of Wnt signaling by inducing beta-catenin degradation [ (PUBMED:21498506) ]. Amer2 is a negative regulator of Wnt/beta-catenin signaling involved in neuroectodermal patterning [ (PUBMED:22128170) ].

WTX is a novel gene mutated in a proportion of Wilms' tumors and in patients suffering from sclerosing bone dysplasia [ (PUBMED:20843316) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry WTX