YacG

• PFAM accession number: PF03884
• Interpro abstract (IPR005584):

  This entry represents the DNA gyrase inhibitor YacG family. E coli. YacG inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. It acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase [ (PUBMED:18586829) ]. YacG has been shown to bind zinc and contains the structural motifs typical of zinc-binding proteins [ (PUBMED:12211008) ]. The conserved four cysteine motif in this protein (-C-X(2)-C-X(15)-C-X(3)-C-) is not found in other zinc-binding proteins with known structures.

• GO function: zinc ion binding (GO:0008270)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry YacG