YgbB

• PFAM accession number: PF02542
• Interpro abstract (IPR003526):

  IspF is a MECDP (2-C-methyl-D-erythritol 2,4-cyclodiphosphate) synthetase, also known as YgbB. It is an enzyme in the non-mevalonate pathway of isoprenoid synthesis. Isoprenoids are essential in all organisms, and can also be synthesized through the mevalonate pathway. The non-mevolante route is used by many bacteria and human pathogens, including Mycobacterium tuberculosis and Plasmodium falciparum. This route appears to involve seven enzymes. MECDP synthetase catalyses the intramolecular attack by a phosphate group on a diphosphate, with cytidine monophosphate (CMP) acting as the leaving group to give the cyclic diphosphate product MEDCP. The enzyme is a trimer with three active sites shared between adjacent copies of the protein. The enzyme also has two metal binding sites, the metals playing key roles in catalysis[ (PUBMED:12499535) ].

  A number of proteins from eukaryotes and prokaryotes are bifunctional proteins with an N-terminal IspD domain and a C-terminal IspF domain [ (PUBMED:15233799) ].

• GO process: terpenoid biosynthetic process (GO:0016114)
• GO function: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity (GO:0008685)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry YgbB