ZnuA

• PFAM accession number: PF01297
• Interpro abstract (IPR006127):

  Members of this family constitute the solute-binding protein component of cluster-9 ABC transporters. This family includes periplasmic solute binding protein TroA from Treponema pallidum, which binds Zn2+ and Mn2+ [ (PUBMED:17581125) ]. In Streptococcus suis, TroA is required for manganese acquisition [ (PUBMED:21784944) ]. Related proteins are found in both Gram-positive and Gram-negative bacteria, including manganese-binding lipoprotein MntA [ (PUBMED:16194238) ] and high-affinity zinc uptake system protein ZnuA [ (PUBMED:24128931) ].

  ZnuA is part of the bacterial zinc-uptake complex ZnuABC. ZinT acts as a Zn2+-buffering protein that delivers Zn2+ to ZnuA, a high-affinity zinc-uptake protein. In Gram-negative bacteria the ZnuABC transporter system ensures an adequate import of zinc in Zn2+-poor environments, such as those encountered by pathogens within the infected host [ (PUBMED:21338480) (PUBMED:24128931) ].

• GO process: metal ion transport (GO:0030001)
• GO function: metal ion binding (GO:0046872)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry ZnuA