The domain within your query sequence starts at position 3 and ends at position 101; the E-value for the eIF_4EBP domain shown below is 4.8e-40.



PFAM accession number:PF05456
Interpro abstract (IPR008606):

This family consists of several eukaryotic translation initiation factor 4E binding proteins (EIF4EBP1, -2 and -3). Translation initiation in eukaryotes is mediated by the cap structure (m7GpppN, where N is any nucleotide) present at the 5' end of all cellular mRNAs, except organellar. The cap is recognised by eukaryotic initiation factor 4F (eIF4F), which consists of three polypeptides, including eIF4E, the cap-binding protein subunit. The interaction of the cap with eIF4E facilitates the binding of the ribosome to the mRNA. eIF4E activity is regulated in part by translational repressors, 4E-BP1, 4E-BP2 and 4E-BP3 which bind to it and prevent its assembly into eIF4F [ (PUBMED:9593750) ].

GO process:negative regulation of translational initiation (GO:0045947)
GO function:eukaryotic initiation factor 4E binding (GO:0008190)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry eIF_4EBP