SMART: Pfam domain sCache

sCache_like

PFAM accession number:	PF16736
Interpro abstract (IPR031967):	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins, including the animal dihydropyridine-sensitive voltage-gated Ca2 channel alpha-2delta subunit, and various bacterial chemotaxis receptors. The name Cache comes from CAlcium channels and CHEmotaxis receptors. The Cache domain, also known as the extracellular PAS domain, consists of an N-terminal part with three predicted strands and an alpha-helix, and a C-terminal part with a strand dyad followed by a relatively unstructured region. The N-terminal portion of the Cache domain containing the three predicted strands could form a sheet analogous to that present in the core of the PAS domain structure. Cache domains are particularly widespread in bacteria, such as Vibrio cholerae. The animal calcium channel alpha-2delta subunits might have acquired a part of their extracellular domains from a bacterial source [ (PUBMED:11084361) ]. The Cache domain appears to have arisen from the GAF-PAS fold, despite their divergent functions [ (PUBMED:11292341) (PUBMED:27049771) ]. This entry represents the N-terminal Cache-like domain of the alkaline phosphatase synthesis sensor protein PhoR. It covers part of the PAS-like fold that share a central five-stranded beta-sheet of identical topology to other PAS domains [ (PUBMED:20008068) ].

PFAM accession number:

PF16736

Interpro abstract (IPR031967):

Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins, including the animal dihydropyridine-sensitive voltage-gated Ca2 channel alpha-2delta subunit, and various bacterial chemotaxis receptors. The name Cache comes from CAlcium channels and CHEmotaxis receptors.

The Cache domain, also known as the extracellular PAS domain, consists of an N-terminal part with three predicted strands and an alpha-helix, and a C-terminal part with a strand dyad followed by a relatively unstructured region. The N-terminal portion of the Cache domain containing the three predicted strands could form a sheet analogous to that present in the core of the PAS domain structure. Cache domains are particularly widespread in bacteria, such as Vibrio cholerae. The animal calcium channel alpha-2delta subunits might have acquired a part of their extracellular domains from a bacterial source [ (PUBMED:11084361) ]. The Cache domain appears to have arisen from the GAF-PAS fold, despite their divergent functions [ (PUBMED:11292341) (PUBMED:27049771) ].

This entry represents the N-terminal Cache-like domain of the alkaline phosphatase synthesis sensor protein PhoR. It covers part of the PAS-like fold that share a central five-stranded beta-sheet of identical topology to other PAS domains [ (PUBMED:20008068) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry sCache_like