The domain within your query sequence starts at position 32 and ends at position 94; the E-value for the stn_TNFRSF12A domain shown below is 1.1e-33.



PFAM accession number:PF12191
Interpro abstract (IPR022316):

The tumour necrosis factor (TNF) receptor (TNFR) superfamily comprises more than 20 type-I transmembrane proteins. Family members are defined based on similarity in their extracellular domain - a region that contains many cysteine residues arranged in a specific repetitive pattern [(PUBMED:7917108)]. The cysteines allow formation of an extended rod-like structure, responsible for ligand binding [(PUBMED:8387891)].

Upon receptor activation, different intracellular signalling complexes are assembled for different members of the TNFR superfamily, depending on their intracellular domains and sequences [(PUBMED:15500863)]. Activation of TNFRs can therefore induce a range of disparate effects, including cell proliferation, differentiation, survival, or apoptotic cell death, depending upon the receptor involved [(PUBMED:11239407)].

TNFRs are widely distributed and play important roles in many crucial biological processes, such as lymphoid and neuronal development, innate and adaptive immunity, and maintenance of cellular homeostasis [(PUBMED:15500863)]. Drugs that manipulate their signalling have potential roles in the prevention and treatment of many diseases, such as viral infections, coronary heart disease, transplant rejection, and immune disease [(PUBMED:9826574)].

TNF receptor 12, also known as TWEAK receptor (TWEAKR), fibroblast growth factor-inducible-14 (Fn14) or CD266, is expressed on a wide variety of different cell types and binds the ligand TWEAK (tumor necrosis factor-like weak inducer of apoptosis) to activate several signaling cascades through activation of NF-kappaB signaling mediated by adaptor TRAF proteins [(PUBMED:18404150)]. The FN14/TWEAK pathway controls a range of cellular activities such as proliferation, differentiation, and apoptosis, and has diverse biological functions in pathological mechanisms like inflammation and fibrosis that are associated with cardiovascular diseases (CVDs) [(PUBMED:24478772)].

The Fn14 receptor is the smallest TNFR superfamily member described so far. It is initially synthesized as a 129-amino-acid type I transmembrane protein that is then proteolytically processed by signal peptidase. The mature form of TweakR has only 102 amino acids and six cysteine residues in its extracellular region [(PUBMED:11728344), (PUBMED:18404150)].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry stn_TNFRSF12A