Proteasome_A_N Proteasome subunit A N-terminal signature Add an annotation
SMART ACC:	SM000948
Description:	This domain is conserved in the A subunits of the proteasome complex proteins.
InterPro ACC:	IPR000426
InterPro abstract:	The proteasome (or macropain) ( EC:3.4.25.1 ) [ PUBMED:7682410 PUBMED:2643381 PUBMED:1317508 expand The proteasome (or macropain) ( EC:3.4.25.1 ) [ PUBMED:7682410 PUBMED:2643381 PUBMED:1317508 PUBMED:7697118 PUBMED:8882582 ] is a multicatalytic proteinase complex in eukaryotes and archaea, and in some bacteria, that is involved in an ATP/ubiquitin-dependent non-lysosomal proteolytic pathway. In eukaryotes the 20S proteasome is composed of 28 distinct subunits which form a highly ordered ring-shaped structure (20S ring) of about 700kDa. Proteasome subunits can be classified on the basis of sequence similarities into two groups, alpha (A) and beta (B). The proteasome consists of four stacked rings composed of α/β/β/α subunits. There are seven different alpha subunits and seven different beta subunits [ PUBMED:9087403 ]. Three of the seven beta subunits are peptidases, each with a different specificity. Subunit beta1c (MEROPS identifier T01.010) has a preference for cleaving glutaminyl bonds ("peptidyl-glutamyl-like" or "caspase-like"), subunit beta2c (MEROPS identifier T01.011) has a preference for cleaving arginyl and lysyl bonds ("trypsin-like"), and subunit beta5c (MEROPS identifier T01.012) cleaves after hydrophobic amino acids ("chymotrypsin-like") [ PUBMED:2535672 ]. The proteasome subunits are related to N-terminal nucleophile hydrolases, and the catalytic subunits have an N-terminal threonine nucleophile. Subunits that belong to the A group are proteins of from 210 to 290 amino acids. They are classified as non-peptidase homologues in MEROPS peptidase family T1 (clan PB(T)). collapse
GO process:	ubiquitin-dependent protein catabolic process (GO:0006511)
GO component:	proteasome core complex, alpha-subunit complex (GO:0019773)
Family alignment:	View the Family alignment or the Alignment consensus sequence
There are 11 354 Proteasome_A_N domains in 11 218 proteins in SMART's NRDB database.

Taxonomic distribution of proteins containing Proteasome_A_N domains

The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing Proteasome_A_N domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.

Predicted cellular role

Cellular role:	Metabolic

KEGG pathways involving proteins which contain this domain

This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a Proteasome_A_N domain which could be assigned to a KEGG orthologous group, and not all proteins containing Proteasome_A_N domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.

KEGG pathways

Some of these pathways are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

KEGG orthologous groups

Some of these KOs are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

3D structures in PDB containing this domain

Links to other resources describing this domain

InterPro	IPR000426
Pfam	Proteasome_A_N