RICTOR_N

Rapamycin-insensitive companion of mTOR, N-term
RICTOR_N
SMART accession number:SM01308
Description: Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. This region is the N-terminal conserved section that may include several individual domains. Rictor can be inhibited in the short-term by rapamycin.
Interpro abstract (IPR028267):

This domain is the N-terminal conserved section that may include several individual domains.

The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. Rictor (rapamycin-insensitive companion of mTOR) is a component of mTORC2 [ (PUBMED:15268862) ]. There is a regulatory link between the two mTOR complexes, whereby Rictor phosphorylation by mTORC1 regulates mTORC2 signalling [ (PUBMED:19995915) ]. Over-expression of Rictor increases mTORC2 activity and promotes cell growth and motility [ (PUBMED:18089801) ].

Family alignment:
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There are 1418 RICTOR_N domains in 1418 proteins in SMART's nrdb database.

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