RICTOR_phospho

Rapamycin-insensitive companion of mTOR, phosphorylation-site
RICTOR_phospho
SMART accession number:SM01309
Description: Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient- and growth-factor signalling. This short region is the phoshorylation site. Rictor does interact with 14-3-3 in a Thr1135-dependent manner. Rictor can be inhibited by short-term rapamycin treatment showing that Thr1135 is an mTORC1-regulated site.
Family alignment:
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There are 298 RICTOR_phospho domains in 141 proteins in SMART's nrdb database.

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