The domain within your query sequence starts at position 105 and ends at position 225; the E-value for the RPT_1 domain shown below is 4.31e-9.

SGGDQASSWGQMVTFNADQTHHGHQKMTFSSDQNVNRSQVTTSSSDQTMYRDQRTTYSAQ
NIYRDSMKILSDCYTYYNDQITVPNRNQTFYRENAPQSQKTTPSDEPTFYGNQMTPSDGN
Q

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.