The domain within your query sequence starts at position 1434 and ends at position 1547; the E-value for the RPT_1 domain shown below is 1.32e-16.

GHPCPGSCHSCFEGRFHERCQQPCKRLLICSHKCQEPCTGECPPCQRTCQNRCVHSQCKK
KCGELCSPCVEPCVWRCQHYQCTKLCSEPCNRPPCYVPCTKLLACGHPCIGLCG

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.