The domain within your query sequence starts at position 1523 and ends at position 1586; the E-value for the RPT_1 domain shown below is 3.76e-7.

PKKGAESKKSNSSPPRDKKPHDHKAPYETKRPCEETKPVDKNSGKEREKHAAEARNGKES
SGGK

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.