The domain within your query sequence starts at position 159 and ends at position 288; the E-value for the RPT_1 domain shown below is 1.53e-21.

SFSPWTDPEIKIFLQEWQVVEREIGHPGQKIKQKSSLVCQRLYHRGLFKDIQSCLDLMWT
LKDLHSTLSRERSRTVPLFSPYRDYLERIFDPKCQRGHVPGALYNWSGYHRPSSSPQTPM
VMPSPVYQPW

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.