The domain within your query sequence starts at position 1810 and ends at position 1860; the E-value for the RPT_1 domain shown below is 5.56e-5.

PQPKSLGSGQCVPEPSPSGQRPYPEVFYGSPGPPNSQQVSGGAPIDSQLHP

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.