The domain within your query sequence starts at position 221 and ends at position 333; the E-value for the RPT_1 domain shown below is 4.31e-9.

SDGNQSLYGGQRTTYNRNQTYEGQTMIPSSNVSYYRAQGTGVQTLCGSQKTTSNDDQTFY
GYHMTSPDGNLTFYGGQTTTPNGDQIFYDMQMTTPSGDQTYNTGWMLPCVSSQ

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.