The domain within your query sequence starts at position 222 and ends at position 406; the E-value for the RPT_1 domain shown below is 6.95e-30.

GIIDLDITNSDCFPSQLLVHGSLAFPLGLDTYHGCVIAAARYGRGRVVVTGHKVLFTVGK
LGPFLLNAVRWLDGGRKGKIVVQTELRTLSGLLAVGGIDTSIEPHLTSDASVYCFEPTSD
VGVKELQEFVAEGGGLFVGTQAWWWAFKNPGVSPLARFPGNLLLNAFGISITSQSLNPGP
FRTPK

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.