The domain within your query sequence starts at position 2322 and ends at position 2445; the E-value for the RPT_1 domain shown below is 2.63e-5.

EESFKHQLDKVTAEKLVLEQQVETTNQVMTHMNNVLKEINFKMDQITQSLCNLNKECASN
EELPSLPKESVHMTVHELGSDNLQPEDAPAQDVTKPLEKQTSLTRLQKSPEASRTQEIES
LASS

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.