The domain within your query sequence starts at position 245 and ends at position 333; the E-value for the RPT_1 domain shown below is 1.03e-15.

PKQEGEAKVEAHRAGQGHPCRNAEAEEGGPETTFVCTGNAFLKAWVYRPGEDTEEEDNSD
SDSAEEDTAQTGATPHTSAFLKAWVYRPG

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.