The domain within your query sequence starts at position 246 and ends at position 302; the E-value for the RPT_1 domain shown below is 4.38e-14.

PIPITKPVPLTKHMPVTKLVTVSKPVPLTKPVPVSRPIVVSKPVPVSRPIAISRHIP

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.