The domain within your query sequence starts at position 275 and ends at position 421; the E-value for the RPT_1 domain shown below is 2.5e-7.

KVRPACTDKDYFYTHTACDAQGETQLMYKWAIPKICGEDLEGAVKLPASGVKTRCPPCNP
GFFKTDNSTCEPCPYGSYSNGSDCTHCPAGTEPAVGFEYKWWNTLPSNMETTVLSGINFE
YKGLTGWEVAGDHIYTAVGASDNDFMI

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.