The domain within your query sequence starts at position 280 and ends at position 348; the E-value for the RPT_1 domain shown below is 2.42e-18.

TQFYQGKQEKEKTIRHYYQDRHAKEHKITLFIYDQQGQEDVITHLDQNNQEERNTLFDHG
NQVKEERIK

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.