The domain within your query sequence starts at position 281 and ends at position 452; the E-value for the RPT_1 domain shown below is 7.49e-5.

EFQRRHGKPKKDHGKRSSHENRESETEGTSSGKRVKQTSDTLKHRKASLSKMSQRSKEGK
KPFSFHSALVNRRELRREKSRKCGEPEKDPRRHLSPAERKRHPKIGSLSKTETCSKCGVA
FTQILENCIESSQCEKCRKNLFQDEAPNQDKEPDPEEASKCGKCGKAFEPGT

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.