The domain within your query sequence starts at position 295 and ends at position 465; the E-value for the RPT_1 domain shown below is 2.4e-7.

DIQAPPADKLSSVEAPADISPTLVQGALSDKPSDQQYPQGTEMAPSELPVEDLDPFSEEV
LEKVQALTTDSMLEDLGIAESTIAEETSGKVQHPLSEETSKEVPAEVHFPIAADFEESAI
LINEKFATDEVFEEYKPPIIEEVSADKATAEVQPPSAEDASEEVAPSEVLP

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.