The domain within your query sequence starts at position 302 and ends at position 364; the E-value for the RPT_1 domain shown below is 5.16e-8.

YHYLQFAYYKLNDVRQAARSAASYMLFDPKDSVMQQNLVYYRFHRARWGLEDEDFQPREE
AML

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.